Antineoplastic Isoflavonoids Derived from Intermediateortho-Quinone Methides Generated from Mannich Bases
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چکیده
منابع مشابه
Application of Mannich bases to the synthesis of hydroxymethylated isoflavonoids as potential antineoplastic agents.
The regiospecific Mannich aminomethylation of 7-hydroxyisoflavonoids using bis(N,N-dimethylamino)methane afforded C-8 substituted N,N-dimethylaminomethyl adducts, and the regioselective aminomethylation of 5-hydroxy-7-methoxyisoflavonoids afforded predominantly the C-6 substituted N,N-dimethylaminomethyl adducts. Acetylation of these C-6 or C-8 Mannich bases with potassium acetate in acetic anh...
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This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate. The reactions are classified on the basis of the o-QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important ...
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A bifunctional squaramide-catalyzed reaction of azlactones with o-quinone methides in situ generated from 2-(1-tosylalkyl)-phenols has been successfully developed under basic conditions, providing an efficient and mild access to chiral dihydrocoumarins bearing adjacent tertiary and quaternary stereogenic centers in high yields with excellent diastereo- and enantioselectivities.
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The development of resistance to current antifungal therapeutics drives the search for effective new agents. The fact that some acetophenone-derived Mannich bases had shown antifungal activities in our previous studies led us to design and synthesize acetophenone-derived bis Mannich bases, B1-B5, bis(beta-aroylethyl)methylamine hydrochlorides, to evaluate their antifungal activity. These bis Ma...
متن کاملSynthesis and Antimicrobial Studies of Some Novel Mannich Bases Derived from Secondary Amines
The amino alkylation of aromatic substrates by the Mannich reaction is of considerable importance for the synthesis and modification of biologically active compounds. The Mannich derivatives of 2-Chloro 4nitrobenzamide with formaldehyde and various secondary amines were synthesized for study of their biological effects. The structures of the synthesized compounds were assigned on the basis of e...
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ژورنال
عنوان ژورنال: ChemMedChem
سال: 2016
ISSN: 1860-7179
DOI: 10.1002/cmdc.201600008